Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration [1]. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease [2]. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo [3].

34233-69-7

C18H19ClN4O

342.83

氯氮平N-氧化;氯氮平N-氧化物;CLOZAPINE N-OXIDE

[1]Ray, R.S., et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 333(6042), 637-642 (2012). [2]Dain, J.G., et al. Biotransformation of clozapine in humans. Drug Metabolism and Disposition 25(5), 603-609 (1997). [3]Eiermann, B., et al. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. British Journal of Clinical Pharmacology 44(5), 439-446 (1997).

[1]Ma X, Li L, Li Z, et al. eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior. EMBO reports. 2022: e54543.

Ethanol:10 mg/mL
H2O:1 mg/mL
DMSO:6 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years