产品展厅
产品展厅
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | FC | Rb | AlexaFluor®488 | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | FCABS352A4 |
| Trade Name |
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| Description | Milli-Mark™ Anti-Nanog-Alexa Fluor 488 Antibody, NT |
| Alternate Names |
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| Background Information |
NANOG is a gene expressed in embryonic stem cells (ESCs) and is thought to be a key factor in maintaining pluripotency. NANOG thought to function in concert with other factors such as POU5F1 and SOX2 to establish ESC identity. These cells offer an important area of study because of their ability to maintain pluripotency, i.e., these cells have the ability to become virtually any cell of any of the three germ layers (endoderm, ectoderm, mesoderm). NANOG may be useful in the immunohistochemical diagnosis of tumors. NANOG is expressed in germ cells of the fetus and in some germ cell tumors of the gonads and central nervous system (CNS). |
| Product Information | |
|---|---|
| Format | AlexaFluor®488 |
| Control |
|
| Presentation | Purified rabbit polyclonal IgG conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Milli-Mark Anti-Nanog-Alexa Fluor 488 Antibody, N-terminus is an antibody against Nanog-Alexa Fluor 488 for use in FC. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Linear peptide from mouse Nanog. |
| Epitope | N-terminus |
| Host | Rabbit |
| Specificity | Antibody recognizes NANOG. |
| Isotype | IgG |
| Species Reactivity |
|
| Species Reactivity Note | Tested and passed on Human. Predicted to react with Mouse, Rat based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Antigen Affinity Purified |
| UniProt Number |
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| UniProt Summary | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor, when overexpressed, promotes cells to enter into S phase and proliferation. |
| Molecular Weight | 34 kDa Calculated |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by flow cytometry using 2102 Ep cells |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 tests |
